In Vivo and In Vitro Skin Uptake and Permeation Studies

Recently, there has been an increased interest in drug administration via the skin, with regard to both dermatological products (for therapeutic effects on diseased skin) and transdermal products (for systemic drug delivery). Because of this increased activity and difficulties encountered in the development of these products, scientists working on drug delivery are becoming aware of the need to develop them more systematically using scientific principles and criteria. This is particularly the case for dermatological products, which have long been ne-glected. Over the past decade, many seminars, conferences, and workshops have been held in the United States to discuss the underlying issues in these areas of drug delivery.1–10