The clinic efficacy of tiotropium in patients with mild to moderate COPD

Objective Evaluation of tiotropium clinic efficacy in patients with mild chronic obstructive pulmonary disease(COPD).Methods In this 12 week,randomised,double-blind,placebo-controlled study of tiotropium 18 mcg once daily versus placebo in the patients with mild to moderate COPD,their respiratory function were assessed on Days 1,15 and 85(baseline: pre-dose Day 1).Results The mean FEV1(% predicted) of all was 73.4±12.5.The baseline in area under the curve from pre-dose to 2 hours post-dose(AUC0-2h) FEV1 in Tiotropium group significantly improved(P0.0001).The rates of adverse event were similar between two groups.Conclusion Tiotropium can significantly improve the lung function in patients with mild to moderate COPD.