The outcomes and benefits of hysteroscopic procedures in women with recurrent implantation failure (RIF) after in vitro fertilization (IVF)

OBJECTIVE: Our goal is to present the first clinical pregnancy following uterus transplantation. DESIGN: Case report. MATERIALS AND METHODS: In 2011,uterus allotransplantation was performed in a patient with complete mullerian agenesis from a deceased donor.Eight embryos were vitrified before the transplantation procedure. Embryo transfer was planned following confirmation of graft stability and safe serum immunosuppressive levels. RESULTS: Immunosuppressive and infection prophylaxis therapies were started. Bilateral uterine artery doppler ultrasonography, cervical and endometrial biopsies demontrated no signs of thromboses or rejection. Starting from first month, the patient had menstrual bleeding with almost every cycle. Eighteen months after uterus allotransplantation and confirmation of the graft stability, one thawed embryo was transferred to the allotransplanted uterus. Serum human chorionic gonadotrophin levels and transvaginal ultrasonography confirmed a viable intrauterine pregnancy. CONCLUSION: Experimental animal and human research are promising to show allo uterus transplantation might be an alternative for fertility restoration.