Preparation method of medicament-loaded biodegradable nano-fiber medical dressing
2010
The invention relates to a method for preparing a medicament-loaded biodegradable nano-fiber medical dressing. The method comprises the following steps: dissolving hyaluronic acid in a mixed solvent comprising water, methanoic acid and N,N-dimethylformamide (DMF) for preparing solution, standing the solution under ultrasonic waves for 1 hour for completely releasing bubbles and further obtaining transparent hyaluronic acid solution; adding the prepared hyaluronic acid electrospinning solution into an injection pump, adjusting the appropriate spinning voltage, the distance from a spinneret to a collecting plate and the flow rate of the spinning solution of the spinneret, electrospinning onto a folding fan-shaped aluminum foil within the temperature range of 5-60 DEG C, and getting hyaluronic acid nano-fiber non-woven fabric with the fiber average diameter of 200-600nm. The preparation process and the post-treatment process step are simple, the hyaluronic acid nano-fiber non-woven fabric can be obtained within the larger temperature range, and the diameter distribution of the obtained hyaluronic acid nano-fiber is uniform.
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