AB0778 Trabecular Bone Score Is Severely Affected in Male Patients with Chronic Obstructive Pulmonary Disease

Background Patients with chronic obstructive pulmonary disease (COPD) have a high risk of osteoporosis and fractures. We reported 27% of vertebral fractures in COPD male patients with normal bone mineral density (BMD) 1 . TBS has been described as an index of bone microarquitecture, and could be a new assessment tool to detect bone quality impairment. Objectives Analysis of TBS in a sub-cohort of male patients with COPD and its possible association with BMD,corticoid use, COPD severity or vertebral fractures. Methods Male patients, older than 50 years, with COPD were included.Exclusion criteria: Other concomitant pulmonary disease, rheumatologic and/or vertebral disease that may lead to missinterpretation of BMD by DXA. Exclusion criteria: Other concomitant pulmonary disease,rheumatologic and/or vertebral disease that may lead to missinterpretation of BMD by DXA. BMD wasdetermined by dual-energy X-ray absorptiometry (DXA) at lumbar spine and proximal femur. Vertebralfractures were assessed by thoracic and lumbar X-ray. Corticosteroid use in the previous five years andnumber of hospitalizations were recorded in all patients. Results We included 98 patients. Mean age 67.8±7.5 years. 38% patients had a mild pulmonar disease, 39% moderate and 23% had a severe disease ((FEV1/FVC 98 patients were included. Mean age 67.8±7.5 years. 41% of patients had mild lung disease and 22% had severe disease (FEV1/FVC Conclusions TBS is severely impaired in male patients with chronic obstructive pulmonary disease, especially in patients with moderate and severe pulmonary disease and those who have received corticosteroids. Although patients with vertebral fractures have a lower value of TBS, this technique does not detect many cases with fracture. References Casado E, et al. JBMR 2007; 22 (S1): S202 Disclosure of Interest None declared