Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates

Jennifer Le,Brenda B. Poindexter,Janice E. Sullivan,Matthew M. Laughon,Paula Delmore,Martha Blackford,Ram Yogev,Laura P. James,Chiara Melloni,Barrie Harper,Jeff Mitchell,Daniel K. Benjamin,Felix Boakye-Agyeman,Michael Cohen-Wolkowiez

Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates

2017

Jennifer Le
Brenda B. Poindexter
Janice E. Sullivan
Matthew M. Laughon
Paula Delmore
Martha Blackford
Ram Yogev
Laura P. James
Chiara Melloni
Barrie Harper
Jeff Mitchell
Daniel K. Benjamin
Felix Boakye-Agyeman
Michael Cohen-Wolkowiez

Background Dried blood spot (DBS) is a practical sampling strategy for pharmacokinetic studies in neonates. The utility of DBS to determine the population pharmacokinetics (pop-PK) of ampicillin, as well as accuracy versus plasma samples, was evaluated.

Keywords:

Dried blood spot
Anesthesia
Ampicillin
Medicine
Pharmacokinetics
Wilcoxon signed-rank test
Linear regression
Analysis of variance
Geometric mean
Urology
Interquartile range
Gestational age

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