Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying

Phillip M. Lovalenti,Jeff Anderl,Luisa Yee,Van Nguyen,Behnaz Ghavami,Satoshi Ohtake,Atul Saxena,Thomas G. Voss,Vu Truong-Le

Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying

2016

Phillip M. Lovalenti
Jeff Anderl
Luisa Yee
Van Nguyen
Behnaz Ghavami
Satoshi Ohtake
Atul Saxena
Thomas G. Voss
Vu Truong-Le

Purpose The goal of this research is to develop stable formulations for live attenuated influenza vaccines (LAIV) by employing the drying methods freeze drying, spray drying, and foam drying.

Keywords:

Desiccation
Influenzavirus B
Chemistry
Spray drying
Freeze-drying
Live attenuated influenza vaccine
Chromatography
Thermal stability
Shelf life
Excipient

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