Supplementary Material for: Epidemiology of Amyotrophic Lateral Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study
2017
Introduction: Amyotrophic lateral sclerosis (ALS) is a
rare, rapidly progressive neurodegenerative disease. Despite wide
variability in the incidence and prevalence of ALS, there is evidence of
positive temporal trends and an increase in incidence with age. The aim
of this study was to conduct a detailed epidemiological investigation
of ALS in Cyprus. Methods: All registered Cypriot ALS
patients in the Republic of Cyprus from January 1985 until December 2014
were included. Socio-demographic information was extracted from patient
files. Results: The study identified 179 ALS patients, of
whom 7 had a positive family history. The mean age at onset was 58.6
years and a slight male predominance was observed. Average annual crude
incidence was 1.26 cases/100,000 person-years and at the beginning of
2015, prevalence of ALS was 7.9 cases/100,000 population. Both incidence
and prevalence displayed an increasing trend, even after
age-standardization of incidence rates. Conclusions:
Incidence, prevalence and main socio-demographic characteristics of ALS
in Cyprus were similar to those of other European countries, without any
geographic clustering of the disease. Additionally, an increased
incidence through the years was confirmed. However, observations such as
a higher male prevalence and a younger mean age of onset compared to
published literature require further investigation.
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