A genetic toxicological study of pesticide workers

Epidemiological surveys and cytogenetic screening were carried out in agricultural workers using pesticides in open fields and in closed spaces respectively in four agricultural counties of Hungary. Some data of the chromosome analyses show the probability of mutagenic effects caused by pesticides. Chromosome aberrations were significantly more frequent in pesticide workers already in the first year of work. Significantly more aberrations were found in those workers having an inhibited acetylcholinesterase activity at the time of the chromosome test. In 14 persons using benomyl, numerical chromosome defects increased significantly in 48 h following spraying, as compared to controls. One year later, the pre‐spraying state was found again. Chromosome mutations were significantly more abundant also in tractor drivers and spray mixers working in orchards and plough‐lands. These finding emphasize the necessity of a strict observance of preventive measures in occupational, food and environmental hygiene.