The Role of Proton Pump Inhibitors in Reducing Laryngeal Injury During Prolonged Intubation

Methods: Adult subjects were prospectively enrolled and underwent video-recorded transnasal fiberoptic laryngoscopy following extubation in the medical intensive care unit. Variables recorded include: duration of intubation, size of endotracheal tube, and administration of proton pump inhibitor versus H-2 blocker during intubation. The laryngoscopy examinations were blindly reviewed and laryngeal injuries that were documented include: presence of vocal fold immobility, vocal fold granuloma, and laryngeal erythema or ulceration.