On the absorption of drugs using chronic dog ileal loop method.

The absorption rate of three model drugs, i.e., pentacaine (highly lipophilic), stobadine (moderately lipophilic) and acetylsalicylic acid (hydrophilic), was studied using the chronic dog ileal loop method. The drugs were dissolved either in 0.9% unbuffered solution of NaCl or in antacid mixture. When using 0.9% NaCl, the half-lives of absorption (t 1/2 (dis)) of pentacaine and stobadine were (mean ±SD) 23.2 ± 7.8 min and 20.8 ± 732 min, respectively. For stobadine a good agreement was found between its t 1/2 (dis) from the ileum and its absorption half-life determined from blood concentrations after oral administration to dogs