Original Contribution CONSUMPTION OF ANTIMICROBIAL DRUGS AND ANTIBIOTIC RESISTANCE IN PROBLEMATIC FOR HOSPITAL INFECTIOUS PATHOLOGY BACTERIA

Multiresistant bacteria are significant problem for the hospital infectious pathology and the antimicrobial resistance can result in increases morbidity, mortality and economic burden. The data in this study represent the consumption of antimicrobial drugs in a big hospital, expressed in a Defined Daily Dose (DDD) per 100 bed-days. The results, obtained in this respect show that 40.3 Defined Daily Doses per 100 BD were used during 2011 in the MMA hospital. There is 2.5 fold greater consumption of antimicrobials in our two ICU– 110.9 DDD/100 bed-days and 105.2 DDD/100 bed-days respectively and also in other high risky for infection development units, compared with the hospital as a whole. The antibiotics used most frequently at MMA were betalactam antibiotics with 59.5% or 24 DDD/100 bed-days, of which 13 DDD/100 bed-days are the quantities of the third and fourth generation of cephalosporins and 2.8 DDD/100 bed-days is a relative part of carbapenems. The use of quinolones was 6.1 DDD/100 bed-days and the quantities of aminoglycosides, spent in the hospital ware 3.9 DDD/100 bed-days. All the data discussed in this study, suggest that nosocomial infections and antibiotic utilization need an improved infection control and monitoring to achieve definitive success in the infections treatment.