PHARMACOLOGICAL STUDIES ABOUT THE INTERACTIONS BETWEEN ETORICOXIB RESPECTIVELY TRAMADOL ASSOCIATED WITH ENALAPRIL

The purpose of this study was to verify the influence of antinociceptiv effect by associating an opioid drog respectively a NSAID with an angiotensin converting enzyme inhibitor . We also tested the analgesic effect of each drug used and we compared the results. Material and method: We used 5 groups of 10 mice Swiss breed and device Tail Flick Unit, standardized assessment to analgesics activities in animal experiments. The 5 groups were treated as follows: Group I: Tramadol; Group II: Etoricoxib; Group III: Enalapril; Group IV: Tramadol and Enalapril; Group V: Etoricoxib and Enalapril. Subsequently each animal from the lots above were exposed to pain stimulus 0, 15, 30, 60 and 90 minutes after treatment. Results: The mice from each lots had the maximum analgesic point at 30 minutes after the treatment administration. Among the 5 groups at the same time (T 30) animals in group I had the lowest sensitivity to pain stimulus (p <0.0001) followed by the animals in group II, III respectively group V. Conclusions: Among all the treatments done, the most effective was for the group treated with tramadol, although the measurements done at T 60 and T 90, its analgesic effect was matched by Etoricoxib. We observed a decrease in analgesic effect when we associated tramadol respectively Etoricoxib with Enalapril. Between the two was the more effective combinations that I used along with Enalapril Tramadol to all measurements (p <0.05), although the group treated with enalapril had a mild analgesic effect measurements made at 15 ', 30' , 60 'and 90' compared with the time T0 (p <0.05).