Efecto de las Estatinas sobre la Concentraciandoacute;n de Vitamina D Sandeacute;rica: Revisiandoacute;n
2018
Statins are very effective lipid-lowering agents and used in prevention of
cardiovascular diseases, which also have effects "pleiotropic". It has been reported
that its use can increase the serum level of vitamin D, although there are few
studies at the moment, with different drugs and times of tracing. Both statins
and vitamin D are metabolized by enzymes of the Cytochrome P450 system:
simvastatin, atorvastatin and lovastatin for CYP3A4, fluvastatin for CYP2C9, while
pravastatin and rosuvastatin is not eliminated by CYP enzymes. On the other hand
vitamin D is an inducer of CYP3A4 and CYP2C9, which could explain the decrease in
the frequency of muscle adverse effects of these drugs It has also been described
that the pleiotropic effects of atorvastatin would be possible only in the presence
of Vitamin D sufficiency. The possibility that both types of drugs have non-classical
effects (the extra-bony vitamin D, and the pleiotropic effects of statins) and that
these may be greater if both substances are in desirable values, opens a new
perspective of prevention and of treatment of numerous pathologies.
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