CHA2DS2-VASc score in patients with COVID-19 pneumonia and its relationship with biomarkers of thrombosis, inflammation and myocardial injury.
2021
CHA2DS2-VASc score associates with worse prognosis in coronavirus-disease-19 (COVID-19). This study investigated laboratory correlates of increasing CHA2DS2-VASc in patients with COVID-19. Patients with COVID-19 were stratified by CHA2DS2-VASc (Group 1: CHA2DS2-VASc 0-1; Group 2: CHA2DS2-VASc 2-3; Group 3: CHA2DS2-VASc ≥4). We found stepwise increase of D-dimer, hs-Troponin and in-hospital mortality across groups (all Pâ<â0.01). D-dimer and hs-Troponin remained independently associated with CHA2DS2-VASc (Bâ=â0.145, Pâ=â0.03; Bâ=â0.320, Pâ<â0.001, respectively). We found significant correlations between D-dimer and C-reactive protein (CRP) in Group 1 and 2, not in Group3 (r2â=â0.103, Pâ=â0.005; r2â=â0.226, Pâ=â0.001; r2â=â0.021, Pâ=â0.253 respectively), and between D-dimer and hs-Troponin in group 2 and 3, not in Group 1 (r2â=â0.122, Pâ=â0.003; r2â=â0.120, Pâ=â0.007; r2â=â0.006, Pâ=â0.514 respectively). In our cohort, CHA2DS2-VASc was independently associated with D-dimer and hs-Troponin increase. Variable relationships of D-dimer with hs-Troponin and CRP within different CHA2DS2-VASc strata suggest multiple mechanisms to be responsible for D-dimer increase in COVID-19.
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