Drug-drug interaction in the treatment of tuberculosis at tertiary care hospital of Larkana, Pakistan

Objective: To assess the drug/ drug interaction in the prescription of tuberculosis patients. Methodology: This descriptive cross-sectional study was conducted for the period of 6 months and a total 300 patients' prescription were chosen using the sample random techniques, which included 63.3% male and 36.6% females. Results: Different d/d interaction were found in both 1st and second line therapies of the disease such as 11% interactions were noted in Rifampin/INH, 8.6% were seen in Rifampin /Pyrazinamide, 13.6% were observed in INH/Lovastatin and 14.3 % were seen in Cycloserine/tramadol. Conclusion: A number of prescriptions were found to have number of the drug/drug interactions.