ADEPIDYN—the first N-methoxy-substituted carboxamide among the succinate dehydrogenase inhibitors

Abstract ADEPIDYN (pydiflumetofen) is a new broad-spectrum foliar fungicide and the first example of the new group of N-methoxy-(phenethyl)-pyrazole-carboxamides within the class of succinate dehydrogenase inhibitors (SDHIs). It offers effective and long-lasting disease control across multiple crops, protecting them against a broad range of yield- and quality-reducing diseases, including leaf spots, powdery mildew, and molds. In addition, ADEPIDYN delivers as very first SDHI fungicide outstanding performance against Fusarium head blight. It has an excellent crop safety profile whether used on its own, in premixes, or in tank mixes. In addition to its high intrinsic potency, ADEPIDYN is rapidly taken up into the wax layer of the plant leaves, resulting in an excellent quantitative rainfastness. In this chapter, we report the discovery, synthesis, physicochemical, and biokinetic properties as well as biological activity of ADEPIDYN.