The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module

How class-switched memory B cells signal to respond robustly to recurring pathogens is incompletely understood. Here the authors show that immunoglobulin tail tyrosine motifs in membrane-bound immunoglobulin isotypes of class-switched cells amplify signalling in memory B cells, in a mechanism that includes distinct kinases and adaptor proteins.