REDUCTIVE CYCLIZATION OF 3-CYANOMETHYLOXINDOLES TO HEXAHYDRO-2-OXOPYRROLO[2,3-b]INDOLES WITH LITHIUM ALUMINUM HYDRIDE

Masashi Shinada,Yoshiyuki Aihara,Satoshi Takiguchi,Naoko Ban,Kazuhiro Higuchi,Tomomi Kawasaki

REDUCTIVE CYCLIZATION OF 3-CYANOMETHYLOXINDOLES TO HEXAHYDRO-2-OXOPYRROLO[2,3-b]INDOLES WITH LITHIUM ALUMINUM HYDRIDE

2010

Masashi Shinada
Yoshiyuki Aihara
Satoshi Takiguchi
Naoko Ban
Kazuhiro Higuchi
Tomomi Kawasaki

Reduction of 3-cyanomethyloxindoles with lithium aluminum hydride at low temperature proceeded smoothly with cyclization to afford hexahydro-2-oxopyrrolo[2,3-b]indoles.

Keywords:

ALUMINUM HYDRIDE
Medicinal chemistry
Iminium
Steric effects
Lithium
Chemistry
Organic chemistry
Alkylation

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