Loss of Fructose-1,6-bisphosphatase 1 Expression in Kidney Neoplasm

Objectives: Renal cell carcinoma (RCC) is a heterogeneous neoplasm with different morphology and molecular changes. Recently, a study investigated panmetabolomic profiles and metabolic genes of more than 600 clear cell RCC (ccRCC) tumors showed the rate-limiting gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP-1) was inhibited in almost 100% of ccRCCs. Here, we …