A direct HPLC method for the resolution of glycidyl tosylate and glycidyl 3-nitrobenzenesulphonate enantiomers

The enantiomeric composition of glycidyl tosylate and glycidyl 3-nitrobenzenesulphonate is obtained using an enantiomeric HPLC column. The chiral oxiranes were resolved on a cellulose carbamate column using a mobile phase of hexane:2-propanol. The method is simple, sensitive and does not require derivatization.