Acid-Promoted Phosphonyl Migration in N-Phosphonyl-α-Aminoalcohols. from N-(2-Hydroxyethyl)Phosphonamides to O-(2-Aminoethyl)Phosphonates

Abstract A novel acid-promoted N-to O-phosphonyl migration is described in N-(2-hydroxyethyl)phosphonamides giving O-(2-aminoethyl)phosphonates, a reaction which parallels the known N-to O-acyl migration in N-monoacyl-α-aminoalcohols.