Hemodynamic response to chronic sepsis in the conscious subhuman primates

The rhesus monkey was used to design a chronic conscious model for the study of sepsis. Sepsis in this model produces either a hyperdynamic or hypodynamic circulatory response similar to that seen in the human suffering from sepsis. This variable hemodynamic response is also similar to that noted in short-term experiments using conscious subhuman primates, but differs from the consistent depression of the circulation seen by investigators studying anesthetized subhuman primates.