Abstract 308: Aortic Valve Stenosis Causes Both Delayed Ventricular Depolarization and Repolarization

Background: Increased QRS duration (QRSD), a common ECG finding in patients (pts) with aortic valve stenosis (AVS), can result in false QT prolongation. This study aimed to test a hypothesis that in AVS delayed ventricular repolarization is independent from the delayed depolarization. Methods: In a retrospective AVS study, ECGs prior to valve repair/replacements were evaluated. QRSD and QTc (Bazett's) were compared between pts with severe and non severe AVS. ECGs showing QRSD > 120 ms or non-sinus rhythm were excluded for analysis. In pts with both wider QRS and longer QT interval (QTc > 440 ms), JT (QT-QRSD) was used to determine the repolarization time. Results: Pts with severe AVS (n=219) had longer QRSD [100 (16) ms vs. 88 (12) ms, p<0.001], with QTc ≥ 450 ms seen in 53%. JT is much longer in the ALQTS group (Table 1). More pts had QTc ≥ 470 ms (33% vs 23%, p<0.05) in the severe AVS than the non-severe AVS. Conclusion: A wider QRS and higher prevalence of moderate to markedly prolonged QT interval in ...