Preparation method of 1,3-propanediol derivatives and intermediates

The invention discloses a preparation method of 1,3-propanediol derivatives and intermediates. The preparation method of trans-2-(4-n-propylcyclohexyl)-1,3-propanediol comprises the following steps: (1) carrying out coupling reaction on propyl cyclohexanone and dimethyl malonate in a solvent under the action of organic alkali and titanium tetrachloride in an inert gas protective atmosphere; (2) reacting the product of the step (1) with hydrogen in an organic solvent under the catalytic action of palladium-carbon; and (3) carrying out reduction reaction on the product of the step (2) with sodium borohydride and lithium chloride in an ethanol-water mixed solution. The preparation method avoids using pyridine, THF (tetrahydrofuran) and other expensive raw materials, reduces the cost, lowers the requirements for wastewater treatment equipment, has the advantages of high safety, high efficiency and environmental protection, and can easily implement industrial production.