Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity.

Objective To investigate the clinical significance of specific IgE-staphylococcal enterotoxin B (IgE-SEB) in CRS (chronic rhinosinusitis). Design Retrospective analysis of patients who were positive for specific IgE-staphylococcal enterotoxin B. Setting Tertiary rhinology clinic. Participants A total of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017 MAIN OUTCOME MEASURES: We retrospectively reviewed the records of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017. Patient demographics, titre specific IgE to staphylococcal enterotoxin B levels, MAST, serologic test, and medical records were reviewed. Results IgE-SEB (KU/L) was higher in CRS patients than Non-CRS patients (0.13±0.37 vs 0.08±0.22, respectively; p-value: 0.044), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 4.46%, respectively; p-value: 0.030). IgE-SEB (KU/L) was higher in the CRS group than in the fungal sinusitis group (0.13±0.37 vs 0.03±0.05, respectively; p-value: 0.1) rate increased, the CRS severity also increased. Conclusions IgE-SEB showed a positive correlation with Lund-Mackay CT severity score, but not with postoperative recurrence or nasal polyps. Further studies are needed to obtain clear evidence that IgE-SEB can be considered as an independent CRS endotype.