Structure Elucidation of Antibiotics by NMR Spectroscopy

: Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for the structure elucidation of antibiotics in solution. Over the past 30 years there have been numerous publications describing the use of NMR to characterize naturally derived or synthetic antibiotics. A large number of one-dimensional (1D) and two-dimensional (2D) NMR methods are available today and the list continues to expand. In this chapter, we will consider the key NMR experiments that provide useful information for compound structure elucidation.