Australeols A−F, neuroprotective meroterpenoids from Ganoderma australe

Abstract Six new meroterpenoids, australeols A−F ( 1 – 6 ), together with nineteen known compounds ( 7 – 25 ), were isolated from the fruiting bodies of Ganoderma australe . Their structures including absolute configurations were assigned by using spectroscopic methods, CD comparison, and X-ray crystallography analysis. Biological evaluation reveals that compounds 13 , (–)- 19 , and 23 exhibit potent neuroprotective activities in glutamate-stimulated SH-SY5Y cells.