Abstract 216: Hospitalizations of Patients With Heart Failure and Reduced Ejection Fraction Treated With Sacubitril/Valsartan (S/V) vs. Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker (ACEI/ARB)

Background: The PARADIGM-HF clinical trial showed a significant reduction in heart failure (HF) hospitalizations and cardiovascular (CV) death in patients with heart failure and reduced ejection fraction (HFrEF) and treated with S/V compared to enalapril. The impact of S/V on real-world outcomes is not well studied. Objective: To assess the association of hospitalization and therapy with S/V vs. ACEI/ARB in patients with HFrEF in the US. Methods: Adult patients with ≥1 claim for S/V or ACEI/ARB from 7/7/2015-5/31/2016 were selected from the MarketScan databases. Patients with S/V were assumed to have HFrEF based on its prescribing information. Patients with ACEI/ARB had claims-based evidence of HFrEF. The index date was the 1st claim for S/V (searched first) or ACEI/ARB. All patients had data for ≥24 months pre-index and ≥6 months post-index, unless inpatient death occurred within 6 months post-index. HF, HF-related, and all-cause hospitalizations in the 6 months pre- and post-index were examined. HF hosp...