PDK1 inhibitors piridinonil

A compound having the formula: where n is an integer of 1 to 5; L1 is -NH-L1A-, thus forming a substituent of the formula R1-NH-L1A (when X is absent and estaausente L2), where L1A is absent, or is substituted or unsubstituted alkylene or heteroalkylene substituted or sinsustituir; L2, independently, is absent or -O-, -NH-, -S-, -S (O) -, S (O) 2-, alkylene substituted or unsubstituted, substituted or unsubstituted oheteroalquileno; X is absent, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, arilenosustituido or unsubstituted or substituted or unsubstituted heteroarylene; R1 is substituted or unsubstituted pyrimidinyl; R2, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, -OH, -CF3, -NO2, -OR10, -S (O) NR11, -C (O) R12, -NR13R14, substituted or unsubstituted substitute, substituted heteroalkyl or unsubstituted cycloalkyl sustituidoo unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted, or substituted heteroaryl osin substituted; R3 is hydrogen, -OH, -CF3, -OR10, -S (O) NR11, -C (O) R12, substituted or unsubstituted heteroalkyl sustituidoo unsubstituted, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, osin substituted aryl substituted, or substituted or unsubstituted heteroaryl, wherein R3 is optionally bonded to X uncicloalquilo forming substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted O-heteroaryl substituted or unsubstituted; R10 is independently -C (O) R15, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted O-heteroaryl substituted or unsubstituted; R11 is independently hydrogen, substituted or unsubstituted, substituted or unsubstituted heteroalkyl, substituted cycloalkyl or unsubstituted, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted O-heteroaryl, substituted or unsubstituted, where if n is 2, then R11 is optionally -NR17R18, and where if n is 1 February, then R11 is not hydrogen.