Features of composition of bile acids in duodenal bile in patients with chronic pancreatitis

: A number of conditions contributing to changes in metabolism of bile acids (BA) appears in case of chronic pancreatitis (CP). There was a study of particular features of the BA composition in the bile of 20 patients with CP and 10 donors with the help of the thin-layer chromatography method. The first group consisted of patients with alcoholic pancreatitis (AP) at the acute stage of the disease, and the second one consisted of patients with chronic biliary pancreatitis. A substantial increase in the content of conjugated BA was recorded in the bile of AP patients. The dependence of changes of bile secretion and its content on the duration of the disease was established. A reduction of bile secretion and decrease in the content of conjugated BA and cholesterol therein were recorded in the second group of patients. A particular feature of the BA composition was a decrease in the percentage of conjugates of cholic acid and glycodioxicholan acids. Cholic acid prevailed among free BAs. The lithocholic acid content increased depending on the duration and severity of the disease. Possible reasons of cholesterol deficit and high free cholic acid content in the bile of CP patients were noted. The findings indicate a colloidal stability of the bile in case of CP. An abnormal conjugation of BAs with glycine and especially with taurine can be not only the reason for changes in the qualitative BA composition but can also lead to changes in absorption of exogenous cholesterol. These changes are most apparent in patients with biliary-dependent forms of pancreatitis.