Transformación blástica de leucemia eosinofílica: caso clínico y revisión de la literatura

To make the chronic eosinophilic leukemia one should exclude the presence of other hematologic neoplasias. The blastic transformation is brought about in some patients in unspecified evolution time. Case. 21-year old patient; his clinical frame: affected by erythematous, prurigilous macular, with eosinophilia in peripheral blood and bone marrow with evolution to cardiac insufficiency. He’s administered imatinib with secondary myelosuppression. Chromosome numerical alteration and specifically chromosome 16 deletion in q22 is observed through FISH. Conclusion. Hematological neoplasias associated with t (5:12) (q33, p13) and variants PDGFRB lead to myeloid disorders. The blastic transformation can even appear up to 24 years after the eosinophilia. Gen FGFR1, which is located in chromosome 8p11 produces a myeoloproliferative syndrome with eosionophilia and chronic eosinophilic leukemia with evolution to blastic phase. The chromosomic alterations and the following evolution to blastic phase found in this patient, who was treated with imatinib, could be the starting point for respective additional research.