Copper regulates cyclic-AMP-dependent lipolysis

Lakshmi Krishnamoorthy,Joseph A. Cotruvo,Jefferson Kar Fai Chan,Harini Kaluarachchi,Abigael Muchenditsi,Venkata S. Pendyala,Shang Jia,Allegra T. Aron,Cheri M. Ackerman,Mark N. Vander Wal,Timothy Guan,Lukas P. Smaga,Samouil L. Farhi,Elizabeth J. New,Svetlana Lutsenko,Christopher J. Chang

Copper regulates cyclic-AMP-dependent lipolysis

2016

Lakshmi Krishnamoorthy
Joseph A. Cotruvo
Jefferson Kar Fai Chan
Harini Kaluarachchi
Abigael Muchenditsi
Venkata S. Pendyala
Shang Jia
Allegra T. Aron
Cheri M. Ackerman
Mark N. Vander Wal
Timothy Guan
Lukas P. Smaga
Samouil L. Farhi
Elizabeth J. New
Svetlana Lutsenko
Christopher J. Chang

Biochemical analysis, and imaging using a copper-sensitive fluorescent sensor, demonstrate that copper regulates cAMP-mediated lipolysis by inhibiting the activity of the cAMP-degrading phosphodiesterase PDE3B.

Keywords:

Biochemistry
Structure–activity relationship
Copper
Metabolism
Lipolysis
Cell signaling
Cell biology
3T3-L1 Cells
Biology
Phosphodiesterase
Enzyme assay
Calcium
Second messenger system
Cysteine

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