Method hydrocracking reactors including interchangeable with loads containing 200ppm weight-2% by weight of asphaltenes

The invention relates to a hydrocracking process of hydrocarbon feeds having 200ppm weight to 2% by weight of asphaltenes and / or more than 10 ppm weight of metals, comprising a hydrodemetallization treatment in at least two reaction zones permutable containing catalyst 'hydrodemetallization and optionally hydrodenitrogenation catalyst and a hydrorefining treatment to reduce the organic nitrogen content, followed by a hydrocracking treatment in a fixed bed and a distillation step.