Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice

Department of Neurology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan, Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan, Department of Medical Science, Teikyo University of Science, Uenohara Campus, Uenohara-shi 409-0193, Japan, Department of Medical Science, Teikyo University of Science, Senju Campus, Tokyo 120-0045, Japan Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, Japan and Department of Sport and Medical Science, Teikyo University Faculty of Medical Technology, Tokyo 173-8605, Japan