Revamping the pharmacokinetics of poorly soluble drugs using different formulations

Abstract The exhaustive efforts commenced in the field of drug discovery. High-throughput screening in the drug discovery cycle leads to the generation of high-molecular-weight lipophilic molecules, which results in low bioavailability on account of poor pharmacokinetic (PK) profile. Recent reports say that about 40% of the newly discovered molecule belongs to the biopharmaceutical classification system (BCS) class II and BCS class IV. This chapter presents various techniques to improve the PK profile of existing drug molecules, especially those of hydrophobic nature, to enhance their solubility. Methods such as nanocrystals, cocrystals, amorphous solid dispersion, eutectic mixtures, freeze-drying, and salt formation have been discussed vide underlying literature citing the mechanisms involved in the improvement of PK by each method.