Delay in the Diagnosis of Conn’s Syndrome: A Single-Center Experience Over 30 Years

To the Editor: The study reported by Rossi et al1 addressed predictors of outcome in aldosterone-producing adenoma (APA) patients postadrenalectomy. The time-dependent process of adverse vascular remodeling, determined by an increased media/lumen ratio of resistance arteries, was hypothesized to predict a poorer response to adrenalectomy. Indeed, the media/lumen ratio and the known duration of hypertension were significant predictors of response to adrenalectomy in APA patients who were categorized into cured, markedly improved, or mildly improved subgroups. In particular, the mean duration of hypertension in …