Abstract 15477: Association Between TSH Levels and Hepatic Steatosis is Mediated by Metabolic Syndrome Factors

Introduction: Thyroid hormones are involved in the regulation of body composition, lipid metabolism and insulin resistance. Thus, they might play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of thyroid hormones levels in NAFLD is not well defined. Hypothesis: Thyroid function is independently associated with NALFD. Methods: We included all individuals evaluated at a preventive clinic between 2014 and 2015. We excluded the patients with previously known liver disease, AUDIT (Alcohol Use Disorders Test) Results: We evaluated 10,603 patients (73% male, age 43.4±9.4 years). The prevalence of hepatic steatosis was 38%. When analyzed by TSH quartiles (0.46-1.44, 1.45-1.97, 1.98-2.68, 2.69-4.68 uU/mL), the highest quartile was associated with a higher prevalence of NAFLD (0.34, 0.38, 0.38 and 0.39, respectively, p for trend Conclusions: The association between TSH levels within the reference range and NAFLD seems to be mediated by metabolic syndrome criteria. Once adjusted by those factors, no significant association is noted.