Long-term outcome of preadolescents, adolescents, and adult patients undergoing total cavopulmonary connection

Abstract Objectives Patients with a single ventricle infrequently undergo total cavopulmonary connection (TCPC) as preadolescents, adolescents, or adults. The purpose of this study was to clarify the characteristics of this cohort and to analyze the factors influencing outcomes. Methods Between 1994 and 2015, 50 of 460 patients underwent TCPC as preadolescents, adolescents, or adults (Group A). The patients´ characteristics and operative results were compared with those of the remaining 410 patients aged Results The median follow-up time was 10.3 [2.8-15.5] years. The differences between groups in 30-day mortality (p=0.20), intensive care unit stay (p=0.20), and incidence of prolonged effusion (p=0.08) were not significant. The estimated survival at 15 years was lower in Group A (86.5%) than in Group B (94.0%, p=0.04) patients. Long-term systemic ventricular ejection fraction, analyzed with linear mixed-effect models, was significantly reduced in Group A than in Group B patients (p Conclusions The TCPC procedure was performed in preadolescent, adolescent, and adult patients with no significant difference in 30-day or hospital mortality compared to those in young children. However, long-term survival and ventricular performance were reduced in this older cohort.