3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists

David Andrew Neel,Matthew L. Brown,Peter Ambrose Lander,Timothy Alan Grese,Jean Marie Defauw,Robert Anthony Doti,Todd Fields,Sally Ann Kelley,Stephon C. Smith,Karen Zimmerman,Mitchell I. Steinberg,Prabhakar Kondaji Jadhav

3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists

2005

David Andrew Neel
Matthew L. Brown
Peter Ambrose Lander
Timothy Alan Grese
Jean Marie Defauw
Robert Anthony Doti
Todd Fields
Sally Ann Kelley
Stephon C. Smith
Karen Zimmerman
Mitchell I. Steinberg
Prabhakar Kondaji Jadhav

Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.

Keywords:

Mineralocorticoid receptor
Nuclear receptor
Biochemistry
Lactam
Steroid
Chemistry
Radioligand Assay
Internal medicine
In vitro
Endocrinology
Antagonist

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