L'artrite reumatoide come modello di malattia genetica multifattoriale: una rassegna della letteratura

Parole chiave. Artrite reumatoide, HLA, fattori ambientali. Summary. Rheumatoid arthritis: a typical multifactorial disease . The environmental factors act as a trigger for the clinical ex pression of rheumatoid in subjects with susceptibility genes. Genetic factors account for 60% of disease suscepti bility. This review focalizes the knowledges about the ge netic and environmental basis of the susceptibility to this pathology arthritis.