Synthesis, antimicrobial evaluation and QSAR studies of gallic acid derivatives

Abstract A series of gallic acid derivatives ( 1–33 ) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated in vitro for their antimicrobial activity against different Gram positive and Gram negative bacterial and fungal strains by the tube dilution method. Results of antimicrobial screening indicated that compound 6 was the most active antimicrobial agent (pMIC am  = 1.92 μM/mL). The results of QSAR studies demonstrated that antibacterial, antifungal and overall antimicrobial activities of synthesized gallic acid derivatives were governed by the electronic parameters, cosmic total energy (Cos E.) and nuclear energy (Nu. E.).