Implementation of drug and HIV risk counseling in MMT programs in Taiwan

s / Drug and Alcohol Dependence 146 (2015) e118–e201 e173 Sex-differences in cognition and behaviors in children with family history of substance use disorders Kristin Lee1, Lexi Pritchett1, Gro Lohaugen2,3, Shannon Kogachi1, Erin Fukaya1, Antonette Hernandez1, Caroline Jiang1, Daniel Alicata1, Thomas Ernst1, Linda Chang1 1 Medicine, University of Hawaii, Honolulu, HI, United States 2 Pediatrics and Child Rehabilitation, Norwegian University of Science and Technology, Arendal, Norway 3 Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway Aims: Substance use disorder (SUD) is highly heritable, but it is unclear whether SUD-related cognitive and behavioral deficits are inherited and if they are sexually dimorphic. Polymorphisms in catechol-O-methyltransferase (COMT) genes have been associated with sex-specific deficits associated with SUD. The aim is to determine the association between two COMT genotype variants, sex, and family history of SUD (FSUD) on behavioral measures and cognition in typically developing children. Methods: FSUD, externalizing behavior and total ADHD scores were reported by parents of 226 children ages 3–20 years (85 SUD: 10.1±0.5 years, 48 boys; 141 CON: 10.0±0.4 years, 74 boys). Cognitive performancewas assessed by full scale IQ (FSIQ) and the NIH Toolbox®. Saliva sampleswere genotyped for two functional COMT single nucleotide polymorphisms (SNPs): rs4680 (Val158Met) and rs165599 (near the 3’UTR region). Results: On 3-way (SNP, sex, FSUD) ANOVAs, rs165599 tended to have negative effects on ADHD scores (p=0.08) and externalizing behaviors (p=0.06), with male AA-carriers with FSUD having higher ADHD scores (p=0.10) and externalizing behaviors (p=0.03). COMT rs165599 variant tended to have a negative effect on FSIQ (p=0.08) and IQ processing speed (p=0.07), withmale AAcarriers with FSUD having the lowest scores. Regardless of FSUD, males with the rs4680 variant tended to have lower FSIQ (p=0.06), but significantly lower processing speed scores (p=0.003). Conclusions: The COMT genetic variants appear to have a greater negative influence on boys. FSUD boys with the rs165599 AA-genotype had greater ADHD symptoms and externalizing behaviors as well as lower FSIQ and slower processing speed. Both behaviors and cognitive functionmay be influenced by these genes involved in dopamine metabolism in a sex-specific manner. Financial Support: NIH (RC2-DA029475, 2K24-DA16170, U54NS56883, G12-MD007601). http://dx.doi.org/10.1016/j.drugalcdep.2014.09.386 Implementation of drug and HIV risk counseling in MMT programs in Taiwan Tony Szu-Hsien Lee1, Marek C. Chawarski2, C. Peng1, C. Hung3, D. Metzger4 1 National Taiwan Normal University, Taipei, Taiwan 2 Psychiatry, Yale School of Medicine, New Haven, CT, United States 3 Taichung Veteran General Hospital, Taichung, Taiwan 4 University of Pennsylvania, Philadelphia, PA,