Груз наследственных заболеваний кожи у населения 12 районов в Ростовской области

The results of a complex medical and population genetic study of hereditary skin diseases (HSD) in the population of 12 districts of the Rostov Region (RR) are presented. Purpose: genetic and epidemiological analysis of load of HSD and study of the role of genetic structure in differentiation of NCD burden in 12 districts of the RO. Materials and methods: The total size of investigated population of 12 districts of Rostov Region is 497460 people (197740 urban and 299720 rural). The load of autosomal dominant (AD), autosomal recessive (AR) and X-linked (X-link.) skin pathology is calculated. Results: the total value of the load of HSD among the population of the Rostov Region was 5.85 ± 0.34/10,000 (1:1709 people). The differentiation in the values of the load (AD and AR pathology) was identified as between districts, within the districts and between the urban and rural populations. A correlation analysis with values of random inbreeding was conducted to determine the reasons for the differences found. Conclusion: the influence of the genetic structure of the studied populations (subdivision and migration characteristics) on the values of the cargo of hereditary skin diseases is shown.