Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic variation

BACKGROUND Genome-wide association studies (GWAS) have led to the discovery of multiple SNPs that are associated with prostate cancer (PCa) risk. These SNPs may potentially be used for risk prediction. To date, there is not a stable estimate of their effect on PCa risk and their contribution to the genetic variation both of which are important for future risk prediction.