Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin

The main objective of this study was synthesis a composite of porous n-HAp/MWCNTs loaded with ciprofloxacin (CFX) as a local drug delivery during surgical procedures with sustained release behavior in the treatment of bone infection minimizing the risks of systemic toxicity. Ciprofloxacin is used as an antibacterial of the Gram-positive and Gram-negative bacteria that affect the bones. The prepared scaffolds loaded with ciprofloxacin were characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, Scanning Electron Microscope (SEM) and Cytotoxicity Testing. The in-vitro release of the drug of such scaffolds was also investigated as well as the study of the Entrapment efficiency of scaffold by using U.V spectroscopy. The cytotoxicity of hydroxyapatite containing MWCNTS applied on normal bone cells for the highest rate of 3 x 10-3 showed the cell viability greater than 90%. The CFX was successfully loaded within such HAp-nano Scaffolds referred to their reasonable encapsulation efficiencies which they revealed. The drug release behavior showed promising sustained prolonged profiles up to 8 days with minimum initial burst effects.