Potent and Selective 5-LO Inhibitor Bearing Benzothiophene Pharmacophore: Discovery of MK-5286.

Lianhai Li,Carl Berthelette,Anne Chateauneuf,Marc Ouellet,Claudio Sturino,Zhaoyin Wang

Potent and Selective 5-LO Inhibitor Bearing Benzothiophene Pharmacophore: Discovery of MK-5286.

2011

Lianhai Li
Carl Berthelette
Anne Chateauneuf
Marc Ouellet
Claudio Sturino
Zhaoyin Wang

The synthesized substituted title benzothiophene (I) is able to serve as a novel scaffold of 5-lipoxygenase (5-LO) inhibitors and is selected to advance into pre-clinical development.

Keywords:

Combinatorial chemistry
Benzothiophene
Pharmacophore
Organic chemistry
Chemistry
triazole derivatives

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations