Green Synthesis of the Adrenomimetic Drug Methoxamine Hydrochloride

Methoxamine hydrochloride was synthesized from p-dihydroxybenzene by O-methylation, Friedel-Crafts acylation, oximation reaction, oxime reduction and keto-amine hydrogenation reactions. All intermediates and products were characterized by IR, 1 H NMR spectra and elemental analysis. The total yield was 37.6%. Compared to the traditional synthetic procedures of methoxamine hydrochloride, the pro- cedures were temperate, convenient, economical, high-yielding and environment-friendly.