Piebaldism in a 3-month-old infant--case report.
2014
Introduction. Piebaldism is an autosomal dominant disorder characterized by
the congenital absence of melanocytes in the affected areas of skin and hair
due to mutations of the KIT protooncogene, which affects the differentiation
and migration of melanoblasts. Case report. A 3 ½ month old male infant was
admitted to hospital due to depigmentation of skin in the area of forehead,
trunk and extremities. On admission, he had multiple, irregularly shaped
areas of leucoderma present at the forehead, abdomen, lower legs and left
forearm. Based on the characteristic skin features and family history, we
diagnosed the boy’s leucoderma as piebaldism. Conclusion. Vitiligo differs
from piebaldism by the presence of unstable hypopigmented lesions that are
acquired later in life. Albinism presents with widespread skin involvement
and lacks the characteristic hyperpigmented macules within hypopigmented
areas.
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