Studi Potensi Ubi Kelapa (Dioscorea Alata. L) sebagai bahan Penghancur Tablet

One of the efforts to realize the independence of Indonesia's pharmaceutical raw material production is to utilize the plant as a source. Dioscorea alata L as one of the starch sources needs to be studied for potential development as a tablet desintegrant. The aims of the research are to determine  the characteristic of Dioscorea alata L. starch and to find out the potential as tablet disintegrant material. Characteristic analysis include are proxymate, amylose content, granular morphology, crystallinity, swelling power, and water capacity binding. The potential study as desintegrant  was performed by formulating a piroxicam tablet using  Dioscorea alata’s starch compared to corn starch. Evaluation of the desintegrant  properties was performed by disintegration test, friability test, hardness test, and dissolution test of the tablets. Based on the characteristic study of Dioscorea alata L. starch, water, ash, protein, and fat contents are 13.08%, 0.23%, 1.43%, and 0.81%, respectively. Then, Amylose is 18.08%. Swelling power and water capacity binding  shows 1.21 and 3.31. Glanular morphology analysis shows ellipsoid and spherical form. The crystallinity of the starch shows as semicrystal form with orthrombic crystal pattern. Tablet disintegration test shows that formula I and II, has disintegration time 3.50 and 4.25. Friability test of formula I and formula II is 0.011% and 0.008%. Hardness test of Formula I and Formula II shows 5kg and 6kg.  Disolution test of Formula I and formula II shows 88.85% and 85.58%. Over the results, the Dioscorea alata L. starch has the potential as the tablet disintegrant material